http://news.cancerbasics.info/chronic_myeloid_leukemia_news.htmlLatest Chronic Myeloid Leukemia News updated hourly. Subscribe and stay informed on latest cancer news for chronic myeloid leukemia.en-uscancerbasics.info@gmail.comSun, 07 Sep 2008 07:06:50 +0200Sun, 07 Sep 2008 07:06:50 +0200Healthhttp://blogs.law.harvard.edu/tech/rss60http://news.cancerbasics.info/images/feedfavicon.pnghttp://news.cancerbasics.info/chronic_myeloid_leukemia_news.htmlLatest Chronic Myeloid Leukemia News updated hourly. Subscribe and stay informed on latest cancer news for chronic myeloid leukemia.8888ATLANTA - Based on input from an expert advisory panel, the oral tyrosine kinase inhibitor dasatinib may be approved by the Food and Drug Administration for the treatment of imatinib-resistant or -intolerant adults with chronic myeloid leukemia. Other potential indications include treatment of ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=0c0487e63e83c01e86254aee6754bc90" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=0c0487e63e83c01e86254aee6754bc90" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=50891166><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=50891166&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=50891166 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Sir, Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia and has been recently approved as first-line treatment. Most of the patients receiving imatinib experience hematological or non-hematological side effects. Skin changes are the most common non-hematological ...<br style="clear: both;"/> <a href="http://www.pheedo.com/click.phdo?s=ae3db20916f347c2dab3c6c425d9c4e0"><img alt="" style="border: 0;" border="0" src="http://www.pheedo.com/img.phdo?s=ae3db20916f347c2dab3c6c425d9c4e0"/></a> <img src="http://www.pheedo.com/feeds/tracker.php?i=ae3db20916f347c2dab3c6c425d9c4e0" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49755169><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49755169&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49755169 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>SAN DIEGO - A new oral drug for patients with Gleevec-resistant chronic myeloid leukemia led to remission in 86% of patients in a phase I trial. Obviously we're excited by that, Charles L. Sawyers, M.D., said at a press briefing during the annual meeting of the American Society of Hematology. The ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=556c20d2aef628b1b5a9ba510d92cacd" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=556c20d2aef628b1b5a9ba510d92cacd" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49755168><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49755168&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49755168 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Introduction Chronic myeloid leukemia is a clonal stem cell disorder associated with the reciprocal translocation between chromosomes 9 and 22 resulting in formation of the bcr-abl chimeric protein with tyrosine kinase activity. [1] The enhanced tyrosine kinase activity has been ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=1a84bbe449a20e6f6bc6abce1bbcf9c2" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=1a84bbe449a20e6f6bc6abce1bbcf9c2" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49755167><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49755167&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49755167 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Chronic leukemias of myeloid origin disorders are the second major category of chronic leukemias. The first major category of chronic leukemias, leukemias of lymphoid origin, was discussed in part one of this two-part series . This group of neoplastic disorders ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=b08afc00b3299e3086f24be5119894ad" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=b08afc00b3299e3086f24be5119894ad" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49518494><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49518494&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49518494 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Chronic myeloid leukemia provides an illustrative disease model for both molecular pathogenesis of cancer and rational drug therapy. Chronic myeloid leukemia is a clonal stem cell disease caused by an acquired somatic mutation that fuses, through chromosomal translocation, the abl and bcr genes on ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=39432807d09eedaa8efe174404b19a14" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=39432807d09eedaa8efe174404b19a14" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462614><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462614&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462614 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Chronic myeloid leukemia has become a model in research and management among malignant disorders. Since the discovery of the presence of a unique and constant chromosomal abnormality slightly more than 40 years ago, substantial progress has been made in the understanding of the biology of the ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=3787f637cb6b0fa440e51526f289b8a5" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=3787f637cb6b0fa440e51526f289b8a5" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462613><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462613&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462613 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Background: Despite the efficacy of the BCR-ABL tyrosine kinase inhibitor Imatinib mesylate for the treatment of chronic myeloid leukemia , resistance has been observed in a proportion of cases, especially those with advanced stages of the disease. Point mutations within the ABL kinase domain ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=cc9342f6d44b3c2ad18518824194b1bd" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=cc9342f6d44b3c2ad18518824194b1bd" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462612><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462612&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462612 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>http://www.rsscache.com/Section/Advertise/click.aspx?a=18887002Detoxify and Lose Weight with AcaiPure - Click Here for Free Trial- Tasigna produced responses in 40% of patients with Philadelphia chromosome-positive chronic myeloid leukemia resistant or intolerant to prior treatment - Approval and availability in US means Novartis can offer physicians and patients a comprehensive treatment approach for this disease EAST ...<br style="clear: both;"/> <a href="http://www.pheedo.com/click.phdo?s=385d9edb9732633046dd55302d71be8a"><img alt="" style="border: 0;" border="0" src="http://www.pheedo.com/img.phdo?s=385d9edb9732633046dd55302d71be8a"/></a> <img src="http://www.pheedo.com/feeds/tracker.php?i=385d9edb9732633046dd55302d71be8a" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462611><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462611&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462611 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>Chronic myeloid leukemia is a rare hematopoietic stem cell disorder characterized by the t translocation. This somatic event leads to the formation of the BCR-ABL fusion gene, which is translated in a functional protein . The Bcr-Abl oncoprotein differs from the endogenous c-Abl ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=158f659929f1cf5e2251538b45f2e30a" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=158f659929f1cf5e2251538b45f2e30a" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462610><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462610&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462610 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>A 65-year-old man with a history of chronic myeloid leukemia presented with fatigue, a 9-kg weight loss, and increasing low back and buttock pain. He had received an allogeneic stem cell transplant 11 months previously. His medications on admission included cyclosporine and prednisone. On ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=9b748ddc03d611e4f466a60d47a4eb0f" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=9b748ddc03d611e4f466a60d47a4eb0f" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462609><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462609&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462609 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>M2 PRESSWIRE-18 February 2003-Research and Markets: Chronic Myeloid Leukemia - Gleevec resistance is opening a market for synergistic use1994-2003 M2 COMMUNICATIONS LTD RDATE:02152003 With CML`s relatively low prevalence, the potential market for drugs launched for this indication historically ...<br style="clear: both;"/> <img alt="" style="border: 0; height:1px; width:1px;" border="0" src="http://www.pheedo.com/img.phdo?i=6bc27cb7eb9c2eed72e531dc587ad633" height="1" width="1"/> <img src="http://www.pheedo.com/feeds/tracker.php?i=6bc27cb7eb9c2eed72e531dc587ad633" style="display: none;" border="0" height="1" width="1" alt=""/><p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49462608><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49462608&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49462608 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>http://www.pheedo.com/click.phdo?i=2adcdc1ed7df52e468235b04abd0acbahttp://news.cancerbasics.info/linkout/ocml.php?out=http://www.highbeam.com/doc/1P3-1074085301.htmlChronic myeloid leukemia has become a model in research and management among malignant disorders. Since the discovery of the presence of a unique and constant chromosomal abnormality slightly more than 40 years ago, substantial progress has been made in the understanding of the biology of the ...<br style="clear: both;"/> <img alt="" style="border: 0;" border="0" src="http://www.pheedo.com/img.phdo?i=2adcdc1ed7df52e468235b04abd0acba"/> <p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49220336><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49220336&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49220336 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>http://www.pheedo.com/click.phdo?i=4ec74afddbe643768484749c057241a4http://news.cancerbasics.info/linkout/ocml.php?out=http://www.highbeam.com/doc/1P3-1360560971.htmlTyrosine kinase inhibitors have revolutionized the treatment of chronic myeloid leukemia and are increasingly used for other indications. Fluid retention, however, including pleural effusions, are a significant side effect of imatinib, the first-line treatment for chronic myeloid leukemia. We ...<br style="clear: both;"/> <img alt="" style="border: 0;" border="0" src="http://www.pheedo.com/img.phdo?i=4ec74afddbe643768484749c057241a4"/> <p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49188472><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49188472&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49188472 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>http://news.cancerbasics.info/linkout/ocml.php?out=http://www.highbeam.com/doc/1G1-128876058.htmlSAN DIEGO - A new oral drug for patients with Gleevec-resistant chronic myeloid leukemia led to remission in 86% of patients in a phase I trial. Obviously we're excited by that, Charles L. Sawyers, M.D., said at a press briefing during the annual meeting of the American Society of Hematology. The ...<p><a href=http://www.rsscache.com/Section/Advertise/click.aspx?n=49091147><img src="http://www.rsscache.com/Section/Advertise/ads.aspx?n=49091147&f=48835" border=0></a><p><div style="font-size: 8pt;"><img align=left src=http://www.rsscache.com/Section/Stats/logo.aspx?n=49091147 border=0> Bandwidth saved by <a href=http://www.rsscache.com>RSScache.com</a></div>http://api.feedburner.com/awareness/1.0/GetFeedData?uri=chronic-myeloid-leukemia-news48835